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10 Contemporary Ohio END Research Studies

The most exciting part of belonging to the field of Neurodiagnostic Technology is the continuous growth and progress being made every day! We are learning so much about the central nervous system as time goes on, and there is still so much to uncover. Here are 10 contemporary research studies conducted right here in Ohio that relate to the field of END:

1. Melatonin and Sleep in Patients with Epilepsy Cincinnati Children's Hospital Medical Center August 2009-October 2020

Patients with Epilepsy often have comorbid conditions that impact their overall health. Insomnia is a comorbid condition that is often prevalent in Epilepsy. Sleep studies have shown increased arousal, sleep onset latency, stage shifts and broken REM sleep in Epilepsy patients. The effects of poor sleep efficiency can lower seizure threshold and worsen seizure control. This study explores the impact of Melatonin on sleep and seizure control in children with Epilepsy.

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NCBI Full article Research Data

2. Effects of Treating Obstructive Sleep Apnea in Epilepsy

University of Michigan, University of North Carolina, Cleveland Clinic Foundation,

Vanderbilt University

September 2002- July 2008

A pilot study to create proper methods to test the hypothesis that treating obstructive sleep apnea in patients with Epilepsy leads to an improvement in daytime alertness or seizure control.

Read More: Research Data


  • Malow BA, Foldvary-Schaefer N, Vaughn BV, Selwa LM, Chervin RD, Weatherwax KJ, Wang L, Song Y. Treating obstructive sleep apnea in adults with epilepsy: a randomized pilot trial. Neurology. 2008 Aug 19;71(8):572-7. doi: 10.1212/01.wnl.0000323927.13250.54.

  • Selwa LM, Marzec ML, Chervin RD, Weatherwax KJ, Vaughn BV, Foldvary-Schaefer N, Wang L, Song Y, Malow BA. Sleep staging and respiratory events in refractory epilepsy patients: Is there a first night effect? Epilepsia. 2008 Dec;49(12):2063-8. doi: 10.1111/j.1528-1167.2008.01681.x. Epub 2008 May 29.

3. Objective Quality of Life Detection Validation

Great Lakes NeuroTechnologies Inc.

September 2019-June 2020

The goal of this study is to create a standardized tool to determine which Parkinson's Disease patients would benefit from advanced therapies such as Deep Brain Stimulation and drug pumps along with quantifying how specific activities reflect quality of life in these patients.

Read More: Research Data


  • Heldman DA, Giuffrida JP, Cubo E. Wearable Sensors for Advanced Therapy Referral in Parkinson's Disease. J Parkinsons Dis. 2016 Jul 2;6(3):631-8. doi: 10.3233/JPD 160830.

4. Effects of a Home Based Walking Program Using Rhythmic Auditory Stimulation on Walking and Cortical Activation in Patients with MS

Cleveland Clinic Foundation

February 2014-September 2015

Rhythmic Auditory Stimulation is a music therapy that uses auditory cues such as a beat, and has been found to improve functional gait and movements while walking. The first part of this study compares home based walking program performance:

1. With Rhythmic Auditory Stimulation

2. Without Rhythmic Auditory Stimulation

3. With Rhythmic Auditory Stimulation, but without walking exercise

The second part of this study uses Rhythmic Auditory Stimulation while performing mental imagery of walking to explore the effects on brain activity.

Read More: Research Data


  • Conklyn D, Stough D, Novak E, Paczak S, Chemali K, Bethoux F. A home-based walking program using rhythmic auditory stimulation improves gait performance in patients with multiple sclerosis: a pilot study. Neurorehabil Neural Repair. 2010 Nov-Dec;24(9):835-42. doi: 10.1177/1545968310372139. Epub 2010 Jul 19.

5. Safety and Efficacy of Using SightSaver Visual Evoked Potential (VEP) for VEP Monitoring in Prone Spine Surgery

Ohio State University

December 2015-March 2016

A rare, but severe complication following non-ocular surgical procedures is post-operative visual loss. There is still much to learn regarding the cause of this complication, but the majority of cases are hypothesized to occur from loss of blood flow to the optic nerve. This study aims to test the SightSaver device and monitor visual evoked potentials during surgeries requiring patients to be prone for 2 or more hours. The goal of the device is to prevent post-operative visual loss and provide more patient satisfaction than current devices being used to monitor visual evoked potentials.

Read More: Research Data

SightSaver Device Product Info

6. The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia

Cleveland Sleep Research Center

November 2010-February 2014

Chronic widespread pain, fatigue and sleep disturbance or non-restorative sleep are the most common symptoms of Fibromyalgia. This study uses two way crossover Polysomnography to evaluate the effects 50 mg Milnacipran twice per day has on sleep disturbance.

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7. A Study on the Use of the MMF07 Foot Massager and Heat Therapy Treatments for Restless Leg Syndrome

Ohio State University

January 2016-September 2018

Restless Leg Syndrome is a nervous system disorder that causes a severe urge to move the legs. The goal of this study is to examine the impact the MMF07 Foot Massager and/or Heat Therapy has on Restless Leg Syndrome symptoms, quality of life and sleep.

Read More: Research Data

MMF07 Foot Massager Product Info

8. Neuroimaging During Pure Oxygen Breathing

Case Western Reserve University

October 2017-May 2018

Neuroimaging and neurodiagnostics are used in this study during room air breathing and pure oxygen breathing to evaluate the effect pure oxygen breathing has on the brain. Cerebral blood flow, cortical electrical activity and cognitive performance are compared during both types of oxygen breathing to see if pure oxygen changes blood flow to the brain, changes electrical activity, and whether it changes the speed of information processing by the brain.

Read More: Research Data


9. Localizing Functional Brain Cortices and Epileptogenic Zones with High Frequency Brain Signals

University of Cincinnati, Children's Hospital Medical Center, Cincinnati

November 2006-current

Through the use of high-frequency brain signals, this study aims to characterize High-frequency brain signal Epilepsy, migraine and other brain disorders as well as localize functional brain areas by creating the world's first database of high-frequency MEG/ECoG/SEEG for the developing brain. This study is still in process.

Read More: Research Data

10. Human-Animal Interaction to Promote Recovery Following Pediatric Brain Injury

Children's Hospital Medical Center, Cincinnati

Eunice Kennedy Shriver National Institute of Child Health and Human Development

July 2019-current

Service dogs have served as positive additions to the lives of people with various disorders and disabilities. The focus of this study is to examine the effects of including therapy dogs in inpatient physical and occupational therapy for 10 sessions with children after a procedure. This study is still in process.

Read More: Research Data

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