10 Contemporary Ohio END Research Studies

The most exciting part of belonging to the field of Neurodiagnostic Technology is the continuous growth and progress being made every day! We are learning so much about the central nervous system as time goes on, and there is still so much to uncover. Here are 10 contemporary research studies conducted right here in Ohio that relate to the field of END:

1. Melatonin and Sleep in Patients with Epilepsy Cincinnati Children's Hospital Medical Center August 2009-October 2020

Patients with Epilepsy often have comorbid conditions that impact their overall health. Insomnia is a comorbid condition that is often prevalent in Epilepsy. Sleep studies have shown increased arousal, sleep onset latency, stage shifts and broken REM sleep in Epilepsy patients. The effects of poor sleep efficiency can lower seizure threshold and worsen seizure control. This study explores the impact of Melatonin on sleep and seizure control in children with Epilepsy.

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NCBI Full article Research Data

2. Effects of Treating Obstructive Sleep Apnea in Epilepsy

University of Michigan, University of North Carolina, Cleveland Clinic Foundation,

Vanderbilt University

September 2002- July 2008

A pilot study to create proper methods to test the hypothesis that treating obstructive sleep apnea in patients with Epilepsy leads to an improvement in daytime alertness or seizure control.

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  • Malow BA, Foldvary-Schaefer N, Vaughn BV, Selwa LM, Chervin RD, Weatherwax KJ, Wang L, Song Y. Treating obstructive sleep apnea in adults with epilepsy: a randomized pilot trial. Neurology. 2008 Aug 19;71(8):572-7. doi: 10.1212/01.wnl.0000323927.13250.54.

  • Selwa LM, Marzec ML, Chervin RD, Weatherwax KJ, Vaughn BV, Foldvary-Schaefer N, Wang L, Song Y, Malow BA. Sleep staging and respiratory events in refractory epilepsy patients: Is there a first night effect? Epilepsia. 2008 Dec;49(12):2063-8. doi: 10.1111/j.1528-1167.2008.01681.x. Epub 2008 May 29.

3. Objective Quality of Life Detection Validation

Great Lakes NeuroTechnologies Inc.

September 2019-June 2020

The goal of this study is to create a standardized tool to determine which Parkinson's Disease patients would benefit from advanced therapies such as Deep Brain Stimulation and drug pumps along with quantifying how specific activities reflect quality of life in these patients.

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  • Heldman DA, Giuffrida JP, Cubo E. Wearable Sensors for Advanced Therapy Referral in Parkinson's Disease. J Parkinsons Dis. 2016 Jul 2;6(3):631-8. doi: 10.3233/JPD 160830.

4. Effects of a Home Based Walking Program Using Rhythmic Auditory Stimulation on Walking and Cortical Activation in Patients with MS

Cleveland Clinic Foundation

February 2014-September 2015

Rhythmic Auditory Stimulation is a music therapy that uses auditory cues such as a beat, and has been found to improve functional gait and movements while walking. The first part of this study compares home based walking program performance:

1. With Rhythmic Auditory Stimulation

2. Without Rhythmic Auditory Stimulation

3. With Rhythmic Auditory Stimulation, but without walking exercise